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Jessica aka miss rabbit c?plak

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Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of the inflamed colon, suggesting that myeloid cell functions in colitis are HIF-dependent. Myeloid HIF ablation also hinders macrophage functional conversion to a protective, pro-resolving phenotype, and elevates gut serum amyloid A levels during the resolution phase of colitis. Therefore, myeloid cell HIF signaling is required for efficient resolution of inflammatory damage in colitis, implicating serum amyloid A in this process. Hypoxia low oxygen tension is evident in many pathological contexts, including chronic intestinal inflammation, commonly known as inflammatory bowel diseases IBD 1 , 2. Inflamed tissues can become hypoxic due to abnormal vascular function 14 and enhanced metabolic activities of bacteria and infiltrating immune cells, such as myeloid cells, which include granulocytes i.
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Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

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Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

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